Eric and Quentin, hosts in a children's show, are at the peak of their television careers. On a night that is a little too crazy, they drink too much and do a little rubbish. Unfortunately, someone films their exploits and broadcasts the video over the Internet. It's bad buzz, the dreaded phenomenon for a public figure. Their producer gives them 48 hours to restore their image, otherwise they will be fired. The more the duo tries to get by, the more they accumulate blunders, as during the funeral of Quentin's grandmother.
Successful businessman Jake takes his pregnant girlfriend Lindsey on a babymoon trip to an upscale desert resort. When they get there, Lindsey discovers that Jake's meddlesome soon to be ex-wife, Gwen is there too. In a dream vacation gone wrong, it becomes apparent that someone is determined that Lindsey will never use her return ticket.
An insane scientist doing experimentation in glandular research becomes obsessed with transforming a female gorilla into a human...even though it costs human life.